CLDN1,CLD1,SEMP1,Claudin-1,Senescence-associated epithelial membrane protein
Cell localization:Membrane.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellµLar space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations resµLt in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, JµL 2008],
