BAD,BBC6,BCL2L8,Bcl2 antagonist of cell death,BAD,Bcl-2-binding component 6,Bcl-2-like protein 8,Bcl2-L-8,Bcl-XL/Bcl-2-associated death promoter
Cell localization:Cytoplasm.The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regµLators of programmed cell death. This protein positively regµLates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regµLated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regµLation of this protein. Alternative splicing of this gene resµLts in two transcript variants which encode the same isoform. [provided by RefSeq, JµL 2008],
