Cell localization:Nucleus.The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regµLators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, JµL 2008],
