NEFH,KIAA0845,NFH,Neurofilament heavy polypeptide,NF-H,200 kDa neurofilament protein,Neurofilament triplet H protein
Cell localization:Cytoplasm.Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellµLar transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008],
