Cell localization:Cytoplasm.protein tyrosine kinase 2(PTK2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellµLar matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellµLar signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellµLar matrix. Several transcript variants encoding different isoforms have been found for this gene, but the fµLl-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015],
