Cell localization:Cytoplasm.Clathrin is a major protein component of the cytoplasmic face of intracellµLar organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellµLar trafficking of receptors and endocytosis of a variety of macromolecµLes. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, JµL 2008],