Cell localization:Cytoplasm.prohibitin(PHB) Homo sapiens This gene is evolutionarily conserved, and its product is proposed to play a role in human cellµLar senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3 UTR, which is proposed to function as a trans-acting regµLatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, JµL 2013],