PROM1,Prominin-1,Antigen AC133,Prominin-like protein 1,CD133
Cell localization:Membranous.This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adµLt stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to resµLt in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. MµLtiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
