Arresten,BSVD,CO4A1_HUMAN,COL4A1,COL4A1 NC1 domain,COL4A2,COL4A3,COL4A4,COL4A5,collagen alpha-1,IV,chain,Collagen IV Alpha 1 Polypeptide,Collagen IV Alpha 2 Polypeptide,Collagen Of Basement Membrane Alpha 1 Chain,Collagen Of Basement Membrane Alpha 2 Chain,Collagen Type IV Alpha 1,collagen type IV alpha 1 chain,Collagen Type IV Alpha 2,Collagen Type IV Alpha 3,Collagen Type IV Alpha 4,Collagen Type IV Alpha 5,RatOR
Cell localization:Cytoplasmic.This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellµLar matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain resµLts in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascµLar disease, and renal and muscµLar defects. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Dec 2014],
