GNA13 Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE85591
| Artikelname: |
GNA13 Rabbit Monoclonal Antibody, Unconjugated |
| Artikelnummer: |
EKL-AMRE85591 |
| Hersteller Artikelnummer: |
AMRe85591 |
| Alternativnummer: |
EKL-AMRE85591-50UL,EKL-AMRE85591-100UL |
| Hersteller: |
EnkiLife |
| Wirt: |
Rabbit |
| Kategorie: |
Antikörper |
| Applikation: |
IHC, WB |
| Spezies Reaktivität: |
Human |
| Konjugation: |
Unconjugated |
| Alternative Synonym: |
guanine nucleotide binding protein (G protein), alpha 13, G13 |
| Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). |
| Klonalität: |
Monoclonal |
| Molekulargewicht: |
Calculated MW: 44 kDa, Observed MW: 44 kDa |
| NCBI: |
10672 |
| UniProt: |
Q14344 |
| Puffer: |
Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
| Reinheit: |
Affinity Purification |
| Formulierung: |
Liquid |
| Target-Kategorie: |
GNA13 |
| Application Verdünnung: |
WB 1:500-1:1000,IHC 1:50-1:100 |
