High temperature requirement protein A2, HTRA 2, HtrA like serine protease, HtrA serine peptidase 2, HtrA, E. coli, homolog of, 2, HtrA2, HTRA2_HUMAN, mitochondrial, Omi stress regulated endoprotease, Omi stress-regulated endoprotease, PARK 13, PARK13, Protease serine 25, PRSS 25, PRSS25, Serine protease 25, Serine protease HTRA2, Serine protease HTRA2 mitochondrial, Serine protease htra2 mitochondrial precursor, Serine protease omi, Serine proteinase OMI.
High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins. While HtrA2 was orignally identified to be present in either the nucleus or endoplasmic reticulum, subsequent studies have shown that it localizes in mitochondria and is released during apoptosis.
