Predicted to enable several functions, including interleukin-16 binding activity, interleukin-16 receptor activity, and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium, positive regulation of calcium-mediated signaling, and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum, external side of plasma membrane, and membrane raft. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system, and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Apr 2022]
