Enables cell adhesion molecule binding activity, protein tyrosine phosphatase activity, and signaling receptor binding activity. Involved in negative regulation of chondrocyte differentiation, positive regulation of cytokine production, and positive regulation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway, myeloid cell differentiation, and regulation of hormone secretion. Predicted to be located in several cellular components, including mitochondrion, plasma membrane raft, and stress fiber. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and liver and biliary system. Used to study several diseases, including Noonan syndrome 1, Noonan syndrome with multiple lentigines, hepatocellular adenoma, intrinsic cardiomyopathy (multiple), and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple), Noonan syndrome with multiple lentigines 1, atrophic gastritis, juvenile myelomonocytic leukemia, and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]
