Cimicoxib (UR-8880) is an orally active, blood-brain barrier-permeable COX-2 inhibitor that also exerts targeted inhibition on CYP2D15. It has an IC50 of 66 nM against hCOX-2, an IC50 of 1.6 µM against canine CYP2D15, and an IC50 of 0.056 µM against feline CYP2D15. By inhibiting the COX-2 pathway to reduce the production of thromboxane B2 and prostaglandin E2, Cimicoxib exerts antipyretic, anti-inflammatory and analgesic effects. Cimicoxib is metabolized by CYP2D15 to form demethyl-cimicoxib, undergoes glucuronidation via UDP-glucuronosyltransferases, and exhibits biphasic elimination kinetics in beagle dogs. Cimicoxib is widely used in studies of inflammatory diseases, osteoarthritis, and perioperative pain associated with orthopedic or soft tissue surgeries[1][2][3][4].
Molekulargewicht:
381.81
Reinheit:
98.02
CAS Nummer:
[265114-23-6]
Formel:
C16H13ClFN3O3S
Target-Kategorie:
COX,Cytochrome P450
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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