BMY 7378 (Standard) is the analytical standard of BMY 7378 (HY-100554). This product is intended for research and analytical applications. BMY 7378 is a selective antagonist of alpha1D-adrenoceptor (alpha1D-AR). BMY 7378 binds to membranes expressing the cloned rat alpha1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat alpha1A-AR (Ki=800 nM) or the hamster alpha1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2].
