NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects[1][2].
Molekulargewicht:
497.44
Reinheit:
96.43
CAS Nummer:
[603151-83-3]
Formel:
C22H26Cl2N4O3S
Target-Kategorie:
CRFR
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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