RNF8 protein is an important E3 ubiquitin protein ligase that participates in the recruitment of repair proteins through Lys-63 linked histone ubiquitination and Lys-48 linked ubiquitination to clear damage sites. target protein, thereby participating in DNA damage signaling. RNF8 is recruited by ATM-phosphorylated MDC1 to form ionizing radiation-induced foci of TP53BP1 and BRCA1 at double-strand breaks. RNF8 Protein, Human (His) is the recombinant human-derived RNF8 protein, expressed by E. coli , with N-6*His labeled tag.
Formel:
9025(Gene_ID)O76064-1 (G2-F485)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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