Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
Alternative Synonym:
Caudal type homeobox 2, Caudal type homeobox transcription factor 2, Caudal-type homeobox protein 2, CDX2
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis PurifiedCDX2 Mouse Monoclonal Antibody (CDX2/9338). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human colon stained with CDX2 Mouse Monoclonal Antibody (CDX2/9338). Inset: PBS instead of primary antibody, secondary only negative control.
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