Crystallin Alpha B Antibody, IgG1, Clone: [CRYAB/7917], Mouse, Monoclonal
Artikelnummer:
NBT-1410-MSM17-P1ABX
Hersteller Artikelnummer:
1410-MSM17-P1ABX
Alternativnummer:
NBT-1410-MSM17-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant human full-length CRYAB protein
Alternative Synonym:
AACRYA, Alpha B crystallin, Alpha-crystallin B chain, CRYA2, CTTP2, Heat shock 20 kD like protein, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY REN 27, Rosenthal fiber component
Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into , and families, and the - and -crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide and N- and C-terminal extensions. -crystallins consist of three gene products, A-, B- and C-crystallin, which are members of the small heat shock protein family (HSP 20). -crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, -crystallins do not renature these proteins. Expression of A-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human B-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilutio
Formalin-fixed, paraffin-embedded human heart stained with Crystallin Alpha B Mouse Monoclonal Antibody (CRYAB/7917). Inset: PBS instead of primary antibody, secondary only negative control.
SDS-PAGE Analysis of Purified Crystallin Alpha B Mouse Monoclonal Antibody (CRYAB/7917). Confirmation of Purity and Integrity of Antibody.
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