Recombinant fragment (around aa300-500) of human DSG3 protein (exact sequence is proprietary)
Alternative Synonym:
130kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members are identified and all are members of the cadherin cell adhesion molecule superfamily.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified Desmoglein-3 Recombinant Mouse Monoclonal Antibody (rDSG3/8611). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human skin stained with Desmoglein-3 Recombinant Mouse Monoclonal Antibody (rDSG3/8611). Inset: PBS instead of primary antibody, secondary only negative control.
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