Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified HER2 Recombinant Mouse Monoclonal Antibody (r5A2). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human breast stained with c-erbB-2 / HER-2 Recombinant Mouse Monoclonal Antibody (r5A2). Inset: PBS instead of primary antibody, secondary only negative control.
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