CD64 / Fc gamma RI Antibody, Clone: [FCGR1A/7498], Mouse, Monoclonal
Artikelnummer:
NBT-2209-MSM5-P1ABX
Hersteller Artikelnummer:
2209-MSM5-P1ABX
Alternativnummer:
NBT-2209-MSM5-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant human FCGR1A protein (exact sequence is proprietary)
Alternative Synonym:
CD64, CD64A, CD64b, CD64c, Fc fragment of IgG, high affinity Ia, receptor (CD64), FCGR1, FCGR1A, FCGR1B, FCGR1C, FcRI, FcRIB, FCRIC, High affinity immunoglobulin gamma Fc receptor IB, IGFR1, IGFRB, IGFRC
Three different classes of IgG Fc receptors have been described: Fc ve OO RI (CD64), Fc ve OO RII (CD32) and Fc ve OO RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-ve OO stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will coimmunoprecipitate with CD64 subsequent to receptor cross linking.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilutio
SDS-PAGE Analysis of Purified CD64 Mouse Monoclonal Antibody (FCGR1A/7498). Confirmation of Integrity and Purity of Antibody.
IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Membrane stained using FCGR1A/7498 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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