CD64 / Fc gamma RI Antibody, IgG2a, Clone: [FCGR1A/7499], Mouse, Monoclonal
Artikelnummer:
NBT-2209-MSM6-P1ABX
Hersteller Artikelnummer:
2209-MSM6-P1ABX
Alternativnummer:
NBT-2209-MSM6-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant fragment (around aa1-200) of human FCGR1A protein (exact sequence is proprietary)
Alternative Synonym:
CD64, CD64A, CD64b, CD64c, Fc fragment of IgG, high affinity Ia, receptor (CD64), FCGR1, FCGR1A, FCGR1B, FCGR1C, FcRI, FcRIB, FCRIC, High affinity immunoglobulin gamma Fc receptor IB, IGFR1, IGFRB, IGFRC
Three different classes of IgG Fc receptors have been described: Fc RI (CD64), Fc RII (CD32) and Fc RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN- stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will coimmunoprecipitate with CD64 subsequent to receptor cross linking.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
SDS-PAGE Analysis of Purified CD64 Mouse Monoclonal Antibody (FCGR1A/7499). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human tonsil stained with CD64 Mouse Monoclonal Antibody (FCGR1A/7499). Inset: PBS instead of primary antibody, secondary only negative control.
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