Recombinant human FGA protein (exact sequence is proprietary)
Alternative Synonym:
fibrinogen, gamma polypeptide testicular tissue protein Li 70
The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: a, b and g. Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities and are mitogens for several cell types. This antibody is directed against a neoantigenic determinant expressed on the human fragment D-dimer. D-dimer is a protein fragment (small piece) thats made when a blood clot dissolves in your body. At D-dimer test is done to determine if a person has any blood clotting disorder.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified D-Dimer / Fibrinogen Gamma Recombinant Rabbit Monoclonal Antibody (FGG/13043R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of HepG2 and A-549 cell lysates and human kidney tissue lysate using Fibrinogen Gamma Rabbit Recombinant Monoclonal Antibody (FGG/13043R).
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