Recombinant fragments of human SLC7A11 protein (exact sequence is proprietary)
Alternative Synonym:
Amino acid transport system xc xCT antibody, Calcium channel blocker resistance protein CCBR1, CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN, xCT
xCT, also known as SLC7A11 (solute carrier family 7, (cationic amino acid transporter, y+ system) member 11) or CCBR1, is a 501 amino acid multi-pass membrane protein that belongs to the polyamine-organocation superfamily of amino acid transporters. Existing as a disulfide-linked heterodimer with CD98, xCT functions as a member of a heteromeric Na+-independent anionic amino acid transport system that specifically facilitates the exchange of anionic amino acids for anionic forms of cystine and glutamate, thereby mediating the formation of glutathione within the cell. Due to its involvement in amino acid transport, xCT is associated with the pathogenesis of gliomainduced neurodegeneration and brain edema, as well as pancreatic cancer. The gene encoding xCT maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified xCT Recombinant Rabbit Monoclonal Antibody (SLC7A11/9136R). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human triple negative breast cancer stained with SLC7A11 / xCT Recombinant Rabbit Monoclonal Antibody (SLC7A11/9136R). Inset: PBS instead of primary antibody, secondary only negative control.
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