Recombinant Glucagon (Marker of Glucagonoma) Antibody, Clone: [GCG/13090R], Rabbit, Monoclonal
Artikelnummer:
NBT-2461-RBM4-P1ABX
Hersteller Artikelnummer:
2461-RBM4-P1ABX
Alternativnummer:
NBT-2461-RBM4-P1ABX-100
Hersteller:
NeoBiotechnologies
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant fragment (around aa1-100) of human GCG protein (exact sequence is proprietary)
Alternative Synonym:
GLP1, GLP2, GRPP, GLP-1
Glucagon is a pancreatic hormone that functions as an antagonist to Insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the Glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas, of which approximately 80% are malignant.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified Glucagon Recombinant Rabbit Monoclonal Antibody (GCG/13090R). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Glucagon Recombinant Rabbit Monoclonal Antibody (GCG/13090R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
