Recombinant fragment (around aa200-353) of human AMBP protein (exact sequence is proprietary)
Alternative Synonym:
A1M, Alpha 1 microglobulin/bikunin precursor, Alpha 1 microglycoprotein, Bikunin, Complex-forming glycoprotein heterogeneous in charge, EDC1, Growth inhibiting protein 19, HCP, HI30, IATIL, ITI, ITI-LC, ITIL, Microglobulin (alpha 1), Protein AMBP, Protein HC, Trypstatin, Uristatin, Uronic-acid-rich protein, UTI
The AMBP (-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated -1-Microglobulin and Bikunin. -1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, -1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter--trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike -1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human placenta stained with AMBP Mouse Monoclonal Antibody (AMBP/4536). Inset: PBS instead of primary antibody, secondary only negative control.
SDS-PAGE Analysis of Purified AMBP Mouse Monoclonal Antibody (AMBP/4536) Confirmation of Purity and Integrity of Antibody.
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