Recombinant CD137 / 4-1BB / TNFRSF9 (Marker of Activated T Cells & NK Cells) Antibody, IgM, Clone: [rS16], Mouse, Monoclonal
Artikelnummer:
NBT-3604-MSM11-P0
Hersteller Artikelnummer:
3604-MSM11-P0
Alternativnummer:
NBT-3604-MSM11-P0-20
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Prokaryotic recombinant protein corresponding to a 140 amino acid sequence from the external domain of the N-terminus of the human CD137 molecule
Alternative Synonym:
4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, CDw137, HLDA VI, Homolog of mouse 4 1BB, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of mouse Ly63, T-cell antigen 4-1BB / ILA homolog, Tumor necrosis factor receptor superfamily member 9
CD137, a member of the tumor necrosis factor receptor family, and its ligand are expressed on activated T lymphocytes and on antigen-presenting cells, respectively. This receptor/ligand system regulates the activation, proliferation and survival of T and B lymphocytes and monocytes through bidirectional signal transduction. Human CD137 is also expressed on activated B cells, Reed Sternberg cells and peripheral blood monocytes but is absent from resting T cells. In non-lymphoid cells it has been detected in blood vessel walls, on the endothelial layer and on vascular smooth muscle cells. Soluble forms of CD137 are also found in sera. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma. It is a target for immunotherapy.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western blot analysis of HEK-293 cell lysate using CD137 Recombinant Mouse Monoclonal Antibody (rS16).
Formalin-fixed, paraffin-embedded human tonsil stained with CD137 Recombinant Mouse Monoclonal Antibody (rS16). Inset: PBS instead of primary antibody, secondary only negative control.
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