Recombinant fragment (around aa1-200) of human BCL2 protein (exact sequence is proprietary)
Alternative Synonym:
Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2vO OO OOlpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2vO OO OOlpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2vO OO OOlpha protein, whereas the normal or hyperplastic germinal centers are negative.Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human tonsil stained with Bcl-2 Mouse Monoclonal Antibody (BCL2/6915). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human tonsil stained with Bcl-2 Mouse Monoclonal Antibody (BCL2/6915). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis of Purified Bcl-2 Mouse Monoclonal Antibody (BCL2/6915). Confirmation of Purity and Integrity of Antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
