CD147 / BSG / EMMPRIN / Neurothelin Antibody, IgG1, Clone: [BSG/7954], Mouse, Monoclonal

Artikelname:	CD147 / BSG / EMMPRIN / Neurothelin Antibody, IgG1, Clone: [BSG/7954], Mouse, Monoclonal
Artikelnummer:	NBT-682-MSM14-P1ABX
Hersteller Artikelnummer:	682-MSM14-P1ABX
Alternativnummer:	NBT-682-MSM14-P1ABX-100
Hersteller:	NeoBiotechnologies
Wirt:	Mouse
Kategorie:	Antikörper
Applikation:	IHC, WB
Spezies Reaktivität:	Hamster, Human, Mouse, Rat
Immunogen:	Recombinant full-length human BSG protein
Alternative Synonym:	5A11 Antigen, 5F7, Basigin, Blood brain barrier HT7 antigen BSG, Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), Leukocyte Activation Antigen M6, Neurothelin, OK Blood Group Antigen, TCSF, Tumor Cell-derived Collagenase Stimulatory Factor

This MAb recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.

Klonalität:	Monoclonal
Klon-Bezeichnung:	[BSG/7954]
Molekulargewicht:	35kDa (non-reduced), 40kDa (reduced)
Isotyp:	IgG1
NCBI:	682
UniProt:	P35613
Formulierung:	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:	Monoclonal Antibody

Anwendungsbeschreibung:

ELISA (For coating, order antibody without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followe

	SDS-PAGE Analysis of Purified CD147 Mouse Monoclonal Antibody(BSG/7954). Confirmation of Purity and Integrity of Antibody
	Western Blot Analysis of Human Brain and Human Heart tissue lysates using CD147 Mouse Monoclonal Antibody (BSG/7954).
	Western blot analysis of Human Brain, Mouse Brain, Rat Brain, Hamster Brain, Guinea pig Brain, Rabbit Brain, Human Heart, Mouse Heart, Rat Heart, Hamster Heart, Guinea pig Heart, Rabbit Heart, Human Liver, Mouse Liver, Rat Liver, Hamster Liver, Guinea pig Liver, and Rabbit Liver tissue lysates using CD147 Mouse Monoclonal Antibody (BSG/7954).
	SDS-PAGE Analysis of Purified CD147 Mouse Monoclonal Antibody (BSG/7954). Confirmation of Purity and Integrity of Antibody.
	Formalin-fixed, paraffin-embedded human placenta stained with CD147 Mouse Monoclonal Antibody (BSG/7954). Inset: PBS instead of primary antibody, secondary only negative control.
	Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with CD147 Mouse Monoclonal Antibody (BSG/7954). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
	Formalin-fixed, paraffin-embedded human colon stained with CD147 Mouse Monoclonal Antibody (BSG/7954). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
	Analysis of Protein Array containing more than 19,000 full-length human proteins using CD147 Mouse Monoclonal Antibody (BSG/7954). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.