It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of PC-3 cell lysate using CD71 Recombinant Rabbit Monoclonal Antibody (TFRC/9106R).
Western blot analyses of (1) human lungs, (2) mouse lungs and (3) rat lungs tissue lysates using CD71 Recombinant Rabbit Monoclonal Antibody (TFRC/9106R).
Formalin-fixed, paraffin-embedded human placenta stained with CD71 Rabbit Recombinant Monoclonal Antibody (TFRC/9106R). Inset: PBS instead of primary antibody, secondary only negative control.
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