Granzyme B Antibody, Clone: [GZMB/3056], Mouse, Monoclonal
Artikelnummer:
NSJ-V7835SAF-100UG
Hersteller Artikelnummer:
V7835SAF-100UG
Alternativnummer:
NSJ-V7835SAF-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC-P
Spezies Reaktivität:
Human
Immunogen:
A recombinant human partial protein (amino acids 73-187) was used as the immunogen for the Granzyme B antibody.
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkins Disease.
