IRAK 4 (IRAK4, REN64, NY-REN-64, Interleukin-1 receptor-associated kinase 4, IRAK-4 mutated form 1, Interleukin-1 receptor associated kinase 4), Goat
Artikelnummer:
USB-I8600-17Q
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| Artikelname: | IRAK 4 (IRAK4, REN64, NY-REN-64, Interleukin-1 receptor-associated kinase 4, IRAK-4 mutated form 1, Interleukin-1 receptor associated kinase 4), Goat |
| Artikelnummer: | USB-I8600-17Q |
| Hersteller Artikelnummer: | I8600-17Q |
| Alternativnummer: | USB-I8600-17Q-100 |
| Hersteller: | US Biological |
| Wirt: | Goat |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IF, IHC, WB |
| Immunogen: | Synthetic peptide corresponding to NKPITPSTYVRC from the N-terminus of human IRAK4. Species Sequence Homology: mouse |
| IRAK4, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK4 has auto- and cross-phosphorylation kinase activity and has been shown to phosphorylate and activate IRAK1. Additionally, IRAK4 interacts with IRAK1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK4 can activate NF-kappaB as well as mitogen-activated protein (MAP) kinase pathways. IRAK4 (-/-) mice are resistant to a lethal dose of lipopolysaccharide and are severely impaired in their responses to viral and bacterial challenges. At least two mRNA transcripts have been reported: 3 and 4.4kb. IRAK4, also referrred to as NY-REN-64, was first identified as an antigen in a screen of renal tumors. Applications: Suitable for use in Peptide ELISA, Flow Cytometry, Western Blot, Immunohistochemistry, Immunofluorescence and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Peptide ELISA: 1:32,000 Western Blot: 0.5-2ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml Flow Cytometry: 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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