Shc, phosphorylated (Tyr239/240) (SHC1, Src Homology and Collagen, Src Homology 2, p52SHC, p66SHC, SH2 Domain Protein C1, SHC, SHCA, SHC Transforming Protein 1), Rabbit
Artikelnummer:
USB-S1010-90B
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| Artikelname: | Shc, phosphorylated (Tyr239/240) (SHC1, Src Homology and Collagen, Src Homology 2, p52SHC, p66SHC, SH2 Domain Protein C1, SHC, SHCA, SHC Transforming Protein 1), Rabbit |
| Artikelnummer: | USB-S1010-90B |
| Hersteller Artikelnummer: | S1010-90B |
| Alternativnummer: | USB-S1010-90B-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Tyr239/240 of human Shc. |
| Shc possesses SH2 and PTB domains. It serves a scaffolding function in signaling for a variety of receptor tyrosine kinases. Shc exists in p46, p52 and p66 isoforms. These isoforms are produced by using alternative translation initiation sites or a differentially spliced message (1-3). In response to extracellular signals, the SH2 and PTB domains of Shc interact with the activated receptors, leading to phosphorylation of Shc on three different tyrosine residues: Tyr239, Tyr240 and Tyr317 (4-6). Grb2/Sos binds to Shc phosphorylated at these sites, activating the Ras/Raf/MAPK pathway (4). Both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development (7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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