SHP2 (SH2 Domain-containing Protein Tyrosine Phosphatase 2, SHP-2, BPTP3, BPTP-3, CFC, MGC14433, Noonan Syndrome 1, Noonan Syndrome 1 Protein Tyrosine Phosphatase 2C, NS1, Protein Tyrosine Phosphatase 2C, PTP2C, PTP-2C, Protein Ty
Artikelnummer:
USB-S1013-30N
Hersteller Artikelnummer:
S1013-30N
Alternativnummer:
USB-S1013-30N-100
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Immunogen:
Synthetic peptide mapping at the C-terminal of human SHP-2, identical to the related rat sequence.
Src homology 2 domain containing tyrosine phosphatase (SHP2), also known as PTPN11, is a 68kD member of the protein tyrosine phosphatase family. SHP2 acts downstream of growth factor receptors and cytoplasmic protein tyrosine kinases which transduce signals from the cell surface to the nucleus. The recruitment and activation of SHP2 is mediated through the binding of CD172a to its ligand CD47. SHP2 regulates a variety of cellular processes. These include transcription, embryonic development, cell growth, cell migration, differentiation, mitotic cycle, haematopoiesis and oncogenic transformation. As a result, dysregulation of the SHP2 gene has been linked to LEOPARD, Noonan and Noonan-like syndrome as well as acute myeloid leukaemia. SHP2 is ubiquitously expressed, with highest levels found in heart, brain, and skeletal muscle. Applications: Suitable for use in RWestern Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot:1-2ug/ml Immunohistochemistry (paraffin):1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
Purified by immunoaffinity chromatography.
Formulierung:
Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
