Synuclein, gamma (Synuclein gamma, Gamma Synuclein, SNCG, SNCG Protein, Breast Cancer Specific Gene 1, Breast Cancer Specific Gene 1 Protein, BCSG1, Breast Cancer Specific Protein 1, Persyn, PRSN, Synoretin, SR), Sheep
Synuclein, gamma (Synuclein gamma, Gamma Synuclein, SNCG, SNCG Protein, Breast Cancer Specific Gene 1, Breast Cancer Specific Gene 1 Protein, BCSG1, Breast Cancer Specific Protein 1, Persyn, PRSN, Synoretin, SR), Sheep
Synuclein, gamma (Synuclein gamma, Gamma Synuclein, SNCG, SNCG Protein, Breast Cancer Specific Gene 1, Breast Cancer Specific Gene 1 Protein, BCSG1, Breast Cancer Specific Protein 1, Persyn, PRSN, Synoretin, SR), Sheep
Artikelnummer:
USB-S9502-04C
Hersteller Artikelnummer:
S9502-04C
Alternativnummer:
USB-S9502-04C-20
Hersteller:
US Biological
Wirt:
Sheep
Kategorie:
Antikörper
Applikation:
IHC, WB
Immunogen:
A synthetic peptide (EKEEVAEEAQSGGD) as part of human gamma synuclein protein (114-127) conjugated to diphteria toxid.
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Subunit: May be a centrosome-associated protein. Cellular Localization: Cytoplasm, perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Tissue Specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Disease: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
Purified by immunoaffinity chromatography.
Formulierung:
Reconstitute in 20ul of sterile water. Centrifuge to remove any insoluble material.
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