Tankyrase (TRF1-interacting Ankyrin-related ADP-ribose Polymerase, TNKS, Tankyrase I, Tankyrase-I, TANK1, TNKS1, TNKS-1, PARP-5a, PARP5a, PARPL, TIN1, TINF1) (Azide Free), IgG2a, Clone: [11C843], Mouse, Monoclonal
Artikelnummer:
USB-T0900-20B
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| Artikelname: | Tankyrase (TRF1-interacting Ankyrin-related ADP-ribose Polymerase, TNKS, Tankyrase I, Tankyrase-I, TANK1, TNKS1, TNKS-1, PARP-5a, PARP5a, PARPL, TIN1, TINF1) (Azide Free), IgG2a, Clone: [11C843], Mouse, Monoclonal |
| Artikelnummer: | USB-T0900-20B |
| Hersteller Artikelnummer: | T0900-20B |
| Alternativnummer: | USB-T0900-20B-100 |
| Hersteller: | US Biological |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC, WB |
| Immunogen: | Partial recombinant protein corresponding to a region near a portion of amino acids within aa1017-1125 of human TNKS with a GST tag. (NP_003738) |
| Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase colocalizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1ug/ml-3ng/ml Western Blot: 1:500-1:1,000 Immunohistochemistry (FFPE): 1.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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