TIRAP (Toll/Interleukin-1 Receptor Domain-containing Adapter Protein, TIR Domain-containing Adapter Protein, Adaptor Protein Wyatt, MyD88 Adapter-like Protein, MAL), Goat
Artikelnummer:
USB-T5500-01T
Hersteller Artikelnummer:
T5500-01T
Alternativnummer:
USB-T5500-01T-100
Hersteller:
US Biological
Wirt:
Goat
Kategorie:
Antikörper
Applikation:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to C-QTLLKKPKKRPNSPE, from human TIRAP, at the internal region of the protein (NP_001034750.1, NP_683708.1).
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of human myeloid erythroblast call line K562 on ~24kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
