TLR4 (Toll Like Receptor 4, CD284), Rabbit
Artikelnummer:
USB-T8050-32
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| Artikelname: | TLR4 (Toll Like Receptor 4, CD284), Rabbit |
| Artikelnummer: | USB-T8050-32 |
| Hersteller Artikelnummer: | T8050-32 |
| Alternativnummer: | USB-T8050-32-100 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IF, IHC, WB |
| Immunogen: | Synthetic peptide corresponding to 15 amino acids near the amino-terminus of human TLR4. Epitope: aa30-80 |
| Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis. Applications: Suitable for use in Immunohistochemistry, Western Blot, ELISA, Immunocytochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 2-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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