KactusBio

Active recombinant proteins and enzymes

KactusBio is a leading biotechnology manufacturer specializing in high-performance active recombinant proteins and enzymes tailored for cell and gene therapy, immunotherapy, and mRNA therapeutics. KactusBio supports research and biologics development from target discovery to clinical manufacturing.

What makes KactusBio proteins special:

Ultra-Low Endotoxin Proteins: To prevent false inflammatory responses in sensitive cell-based assays and animal studies, our catalog proteins undergo rigorous purification to achieve levels as low as <0.01 EU/µg.
HEK293 Expression: Most proteins are expressed in mammalian systems to ensure native post-translational modifications and proper protein folding.

Product Range

Proteins:

Complex Membrane Proteins (VLP & Nanodisc): Utilizing our SAMS™ platform, we provide difficult-to-express transmembrane proteins (GPCRs, ion channels) in VLP and Nanodisc formats, including native CD3-TCR nanodiscs, to preserve native folding and bioactivity.
CAR-T & Cell Therapy Targets: A comprehensive catalog of target proteins such as CD19, BCMA, GPRC5D, and MSLN, available with site-specific labeling (Biotin, FITC, PE) for high-sensitivity CAR affinity assays and T-cell detection.
MHC Complexes (Monomers & Tetramers): High-purity MHC Class I and II molecules, including peptide-ready MHCs and custom peptide-MHC complexes, essential for TCR discovery, antigen-specific T-cell assays, and immune profiling.
Immune Checkpoints & Cytokines: Recombinant human cytokines (e.g., IL-15, IL-2, VEGF165, IFN-gamma) validated for biological activity to support cell culture, 3D organoid expansion, and immune cell activation.

Enzymes:

mRNA & Gene Editing Enzymes: A full suite of enzymes for mRNA synthesis (T7 RNA Polymerase, Vaccinia Capping Enzyme, RNase Inhibitor) and gene editing (Cas9, AccuBase™ Base Editor). Available in Research Grade and GMP Grade (with DMFs) to ensure a seamless transition from bench to clinic.
KLK Enzyme Family: Specialized recombinant human Kallikrein (KLK) enzymes, including ultra-low endotoxin formats, for research into tissue repair and oncology.

Elisa Kits:

Bioanalytical Assay Kits: High-specificity AAV Titration ELISA kits (Serotypes 2, 5, 6, 8, 9) for capsid quantification and Cas9 ELISA kits for residual protein detection in edited cells.

Custom Services:

Custom Protein Production: From novel CAR-T constructs to engineered antibody formats, we provide scalable expression and purification tailored to your specifications.
Bioanalytical Services: Characterization of biomolecular interactions using Surface Plasmon Resonance (SPR) and ELISA to determine binding kinetics and affinity.

https://kactusbio.com/

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