A2ML1 Rabbit pAb, Unconjugated, Polyclonal
Catalog Number:
ABB-A17831
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| Article Name: | A2ML1 Rabbit pAb, Unconjugated, Polyclonal |
| Biozol Catalog Number: | ABB-A17831 |
| Supplier Catalog Number: | A17831 |
| Alternative Catalog Number: | ABB-A17831-100UL,ABB-A17831-20UL,ABB-A17831-1000UL,ABB-A17831-500UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | OMS, p170, CPAMD9, A2ML1 |
| This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP, PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS, PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Application Dilute: | WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human,Rat. ResearchArea: Ubiquitin,Immunology Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway. Shipping: Ice Bag |
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Western blot analysis of lysates from HeLa cells, using A2ML1 Rabbit pAb (A17831) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min. |
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