TGF beta Receptor II Rabbit mAb, Unconjugated, Monoclonal
Catalog Number:
ABB-A19124
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| Article Name: | TGF beta Receptor II Rabbit mAb, Unconjugated, Monoclonal |
| Biozol Catalog Number: | ABB-A19124 |
| Supplier Catalog Number: | A19124 |
| Alternative Catalog Number: | ABB-A19124-100UL,ABB-A19124-20UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, tbetaR-II, TGFbeta-RII, TGF beta Receptor II (TGFBR2) |
| The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. |
| Application Dilute: | WB,1:5000 - 1:15000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human. ResearchArea: Signal Transduction,Kinase,Cell Biology Developmental Biology,TGF-b-Smad Signaling Pathway,Stem Cells. Shipping: Ice Bag |
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Western blot analysis of lysates from Hep G2 cells using TGF beta Receptor II Rabbit mAb (A19124) at 1:9000 dilutionincubated overnight at 4°C. Hep G2 cells were treated by PNGase(1 µL) at 37°C for 30 minutes. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 30 µg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
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