Daxx Rabbit mAb, Unconjugated, Monoclonal
Catalog Number:
ABB-A19661
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| Article Name: | Daxx Rabbit mAb, Unconjugated, Monoclonal |
| Biozol Catalog Number: | ABB-A19661 |
| Supplier Catalog Number: | A19661 |
| Alternative Catalog Number: | ABB-A19661-100UL,ABB-A19661-20UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | DAP6, EAP1, BING2, SMIM40, Daxx |
| This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. |
| Application Dilute: | WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human. ResearchArea: Epigenetics Nuclear Signaling,Chromatin Remodeling,Signal Transduction,MAPK-JNK Signaling Pathway,Cell Biology Developmental Biology,Apoptosis,Death Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases. Shipping: Ice Bag |
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Western blot analysis of various lysates using Daxx Rabbit mAb (A19661) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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