IL-6 Rabbit mAb, Unconjugated, Monoclonal
Catalog Number:
ABB-A22222
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| Article Name: | IL-6 Rabbit mAb, Unconjugated, Monoclonal |
| Biozol Catalog Number: | ABB-A22222 |
| Supplier Catalog Number: | A22222 |
| Alternative Catalog Number: | ABB-A22222-100UL,ABB-A22222-20UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | CDF, HGF, HSF, BSF2, IL-6, BSF-2, IFNB2, IFN-beta-2, IL6 |
| This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). |
| Application Dilute: | WB,1:1000 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human. ResearchArea: Cancer,Tumor immunology,Invasion and metastasis,Cell biology developmental biology,Apoptosis,Growth factors,Endocrine metabolism,Endocrine and metabolic diseases,Obesity,Immunology inflammation,Cytokines,Interleukins,Jak-Stat-IL-6 receptor signaling pathway,Cell intrinsic innate immunity signaling pathway,Neuroscience,Neurodegenerative diseases,Neurodegenerative diseases markers,Other neurological disorders,Cardiovascular,Angiogenesis. Shipping: Ice Bag |
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Western blot analysis of lysates from THP-1 cells using IL-6 Rabbit mAb (A22222) at 1:1000 dilutionincubated overnight at 4°C. THP-1 cells were treated with PMA(80 nM) at 37°C for overnight, LPS (1 µg/mL) and BFA (300 ng/mL) at 37°C for 6 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 30 µg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90 s. |
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