Dopamine beta Hydroxylase Rabbit mAb, Unconjugated, Monoclonal
Catalog Number:
ABB-A23579
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| Article Name: | Dopamine beta Hydroxylase Rabbit mAb, Unconjugated, Monoclonal |
| Biozol Catalog Number: | ABB-A23579 |
| Supplier Catalog Number: | A23579 |
| Alternative Catalog Number: | ABB-A23579-100UL,ABB-A23579-20UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | DBM, ORTHYP1, Dopamine beta Hydroxylase |
| The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. |
| Application Dilute: | WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human. ResearchArea: Cancer,Endocrine Metabolism,Neuroscience. Shipping: Ice Bag |
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Western blot analysis of various lysates using Dopamine beta Hydroxylase Rabbit mAb (A23579) at 1:1000 dilutionincubated overnight at 4°C. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Negative control (NC): 293T Exposure time: 30s. |
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