Acetyl-CoA Carboxylase Rabbit pAb, Unconjugated, Polyclonal
Catalog Number:
ABB-A23986
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| Article Name: | Acetyl-CoA Carboxylase Rabbit pAb, Unconjugated, Polyclonal |
| Biozol Catalog Number: | ABB-A23986 |
| Supplier Catalog Number: | A23986 |
| Alternative Catalog Number: | ABB-A23986-1000UL,ABB-A23986-20UL,ABB-A23986-500UL,ABB-A23986-100UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | ACC, ACAC, ACC1, ACCA, Acac1, hACC1, ACACAD, ACCalpha, ACACalpha, Acetyl-CoA Carboxylase |
| Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene. |
| Application Dilute: | WB,1:1000 - 1:5000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Application Notes: | Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Cardiovascular, Lipids / Lipoproteins,Fatty Acids Synthesis, Signal Transduction,Metabolism,Mitochondrial,Cancer Metabolism. Shipping: Ice Bag |
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Western blot analysis of various lysates, using Acetyl-CoA Carboxylase Rabbit pAb (A23986) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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