Monoclonal Antibody to TLR8/CD288 (Clone: ABM15F6)
Biozol Catalog Number:
ABI-10-3005-25
Supplier Catalog Number:
10-3005-25
Alternative Catalog Number:
ABI-10-3005-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IHC
Species Reactivity:
Human
Immunogen:
A partial length recombinant TLR8 protein (amino acids 750-900) was used as the immunogen for this antibody.
Alternative Names:
TLR8||UNQ249/PRO286
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant, termed G or A1G allele of TLR8. TLR8v1 has additional 19 amino acids in the N-terminus. It is predominantly expressed in lung and peripheral blood leukocytes.
Fig-2: Immunohistochemical analysis of TLR8 in small cell carcinoma of esophagus using TLR8 antibody (Clone: ABM15F6) at 5 µg/ml.
Fig-1: Intracellular flow analysis of hTLR8 in U937 using 2 µg/10 6 cells of hTLR8 antibody (Clone: ABM15F6). Green represents isotype control, red represents anti-hTLR8 antibody. Goat anti-mouse PE conjugate was used as secondary.
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