Monoclonal antibody to MyD88 (Clone: ABM2H20) FITC Conjugated
Biozol Catalog Number:
ABI-10-3012-F
Supplier Catalog Number:
10-3012-F
Alternative Catalog Number:
ABI-10-3012-F-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS
Species Reactivity:
Human
Immunogen:
A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.
Conjugation:
FITC
MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
Fig:1-Intracellular flow analysis of MyD88 in PBMC using 0.5 µg/10 6 cells. Green represents isotype control (ABEOMICS), red represents FITC conjugated anti-MyD88 antibody (10-3012F).
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