Full length recombinant protein of hCD161 was used as the immunogen for this antibody.
Alternative Names:
Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
Figure-1: Cell surfce flow analysis of hCD161 in human PBMC (Lymphocyte gated) using 0.5 µg/10 6 cells of hCD161 (Clone: ABM27F5). Green represents isotype control, red represents anti-CD161antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
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