Polyclonal Antibody to beta-catenin (phospho-Tyr333), Rabbit
Biozol Catalog Number:
ABI-35-1340
Supplier Catalog Number:
35-1340
Alternative Catalog Number:
ABI-35-1340-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 333 (Y-T-Y(p)-E-K) derived from Human b-catenin
Alternative Names:
CTNNB1|| CATNB|| CTNB1|| CTNNB
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Lillehoj E.P., Lu W., Kiser T., Goldblum S.E., Kim K.C.Biochim. Biophys. Acta 1773:1028-1038(2007)
Clonality:
Polyclonal
Form:
Purified
Target:
Beta-catenin (phospho-Tyr333)
Application Dilute:
Predicted MW: 92kd, Western blotting: 1:500~1:1000
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